5 einfache Fragen Über Behandlung von Opioidsucht beschrieben
5 einfache Fragen Über Behandlung von Opioidsucht beschrieben
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Prescribers should always follow appropriate pain management principles of careful assessment and ongoing monitoring.
Methadone should Beryllium given with caution and the initial dose reduced in certain patients, such as the elderly and debilitated and those with severe impairment of hepatic or renal function, hypothyroidism, Addison's disease, prostatic hypertrophy, or urethral stricture.
Teratogenic Effects. Pregnancy Category C – There are no controlled studies of methadone use in pregnant women that can be used to establish safety. However, an expert Bericht of published data on experiences with methadone use during pregnancy by the Teratogen Information Struktur (TERIS) concluded that maternal use of methadone during pregnancy as part of a supervised, therapeutic regimen is unlikely to pose a substantial teratogenic risk (quantity and quality of data assessed as “limited to fair”). However, the data are insufficient to state that there is no risk (TERIS, belastung reviewed October, 2002). Pregnant women involved hinein methadone maintenance programs have been reported to have significantly improved prenatal care leading to significantly reduced incidence of obstetric and fetal complications and neonatal morbidity and mortality when compared to women using illicit drugs.
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Switching a patient from another chronically administered opioid to methadone requires caution due to the uncertainty of dose conversion ratios and incomplete cross-tolerance. Deaths have occurred hinein opioid tolerant patients during conversion to methadone. Conversion ratios rein many commonly used equianalgesic dosing tables do not apply rein the Umgebung of repeated methadone dosing.
The Methadontabletten 10 mg online use of methadone has not been extensively evaluated in patients with hepatic insufficiency. Methadone is metabolized rein the liver and patients with liver impairment may Beryllium at risk of accumulating methadone after multiple dosing.
Your kidneys may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays rein your body for a longer time. This raises your risk of side effects.
Pediatric – The pharmacokinetics of methadone have not been evaluated rein the pediatric Tierbestand.
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The safety and effectiveness of this drug hasn’t been established rein children. It shouldn’t Beryllium used in children younger than 18 years.
These side effects include slowed breathing and sedation. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.
The safety and effectiveness of this drug hasn’t been established hinein children. It shouldn’t be used rein children younger than 18 years.
The respiratory depressant effects of opioids and their capacity to elevate cerebrospinal-fluid pressure may Beryllium markedly exaggerated hinein the presence of head injury, other intracranial lesions or a pre-existing increase rein intracranial pressure.
There is considerable variability rein the appropriate Satz of methadone taper rein patients choosing medically supervised withdrawal from methadone treatment. It is generally suggested that dose reductions should be less than 10% of the established tolerance or maintenance dose, and that 10 to 14-day intervals should elapse between dose reductions.